HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 23112218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 23112217 | HCID 23112217 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 23112218 | HCID 23112218 | — |
Reaction Steps
5-Chloro-6-[(2,4-dimethoxybenzyl)amino]nicotinate was treated with sodium hydroxide in ethanol to obtain 5-chloro-6-[(2,4-dimethoxybenzyl)amino]nicotinic acid. To the compound were added toluene, diphenylphosphoryl azide (DPPA), tert-butyl alcohol, and triethylamine, and the whole was stirred under reflux with heating. The resulting compound was treated with trifluoroacetic acid to obtain 3-chloropyridin-2,5-diamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585878B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-394ae546335547938b6cb5155c9eb8a8 |
| Source note | uspto-grants-2009_09 |