Hydrochloric Acid → HCID 23112227, compound

Participants

Reaction Steps

To 10 ml of chloroform were added 250 mg of N-1,3-benzothiazol-5-yl-2-(chloromethyl)biphenyl-4-carboxamide and 169 mg of piperidine-4-carboxamide, followed by 3 days of stirring at room temperature. The reaction solvent was removed by evaporation under reduced pressure and the obtained residue was purified by silica gel column chromatography (chloroform:methanol) to obtain a yellow foamy substance. Thereto were added 2 ml of ethanol and 1 ml of a 4M ethyl acetate solution of hydrochloric acid, followed by removal of the solvent under reduced pressure. The residue was crystallized (ethanol:water:ethyl acetate) to obtain 205 mg of 1-({4-[(1,3-benzothiazol-5-ylamino)carbonyl]biphenyl-2-yl}methyl)piperidine-4-carboxamide hydrochloride.

Provenance & Evidence