HCID 68817299, compound → HCID 11688866, compound

Participants

Reaction Conditions

Reaction Steps

3-chloro-5-(3-methoxybenzoyl)-6-methyl-5,6-dihydrophenanthridine—N-[1-(4′-Chloro-2′-fluoro-biphenyl-2-yl)-ethyl]-3-methoxy-benzamide (1.04 g, 2.7 mmol) was dissolved in anhydrous THF (10 mL) and the vial was capped and purged with an inert atmosphere. Lithium bis(trimethylsilyl)amide (4.1 mL, 1M in THF) was added to the solution and the mixture heated (70° C). The reaction progress was monitored by LCMS and heating was discontinued upon the expense of the starting material. The THF was removed and the resulting residue was purified by flash column chromatography (Biotage® 40 Mi, 30-50% methyl tert-butylether in hexane) affording 537 mg (54%) of the desired product. MS [(ES+), m/z]: 364/366 [M+H]+, 1 Cl pattern.

Provenance & Evidence