HCID 11688866, compound → HCID 11617230, compound

Participants

Reaction Steps

The enantiomers of 3-[(3-chloro-6-methylphenanthridin-5(6H)-yl)carbonyl]phenol (367 mg, 1.05 mmol) were separated by automated, preparative, normal phase, chiral chromatography on a Chiralpak AD (20 mm×250 mm) column eluting with 100% ethanol at a flow rate of 10 mL/min. After combination of fractions and evaporation of the solvent in vacuo, one peak (99.9%) with a retention time of 9.771 minutes was isolated as a white solid (135 mg, 74% based upon a 1:1 ratio of enantiomers with a theoretical maximum amount of 183.5 mg). [α]D25=+440° (c=g/mL, CHCl3);1H NMR (400 MHz, DMSO-d6) δ ppm 1.21 (d, J=6.73 Hz, 3 H) 5.64 (d, J=6.21 Hz, 1H) 6.69 (d, J=7.50 Hz, 1H) 6.72 (s, 1 H) 6.83 (dd, J=2.59, 1.03 Hz, 1 H) 6.85 (m, 1 H) 6.92 (s, 1 H) 7.16 (t, J=7.89 Hz, 1 H) 7.28 (dd, J=8.41, 2.20 Hz, 1 H) 7.39 (m, 2 H) 7.45 (m, 1 H) 7.98 (d, J=8.54 Hz, 2 H); MS (ESI) m/z 350/352 ([M+H]+); MS (ESI) m/z 348/350 ([M−H]−); HRMS: calcd for C21H16ClNO2, 349.0870 (M), 350.09424 ([M+H]+); found (ESI+), 350.09345.

Provenance & Evidence