HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 178509779 | HCID 178509779 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]benzonitrile | HCID 57837949 | — |
Reaction Steps
3-cyano-N-hydroxy-benzamidine (1.0 g, 6.2 mmol), triethylamine (1.5 ml, 10.6 mmol) and chloroacetyl chloride (0.74 ml, 9.3 mmol) in dichloromethane (12 ml). Purification was performed by decolorizing with silica gel. 1H NMR (CDCl3), d (ppm): 8.40 (s, 1H), 8.32 (d, 1H), 7.82 (d, 1H), 7.64 (t, 1H), 4.77 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585881B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-8fb32350b59d400b97055886c8199f4a |
| Source note | uspto-grants-2009_09 |