5-methyl-3,6-dihydro-2H-pyran-2-carboxylic acid → 5-Methyl-tetrahydro-pyran-2-carboxylic acid

Participants

Reaction Steps

To a solution of 5-methyl-3,6-dihydro-2H-pyran-2-carboxylic acid (40 mg, 0.28 mmol) in MeOH (2.0 mL) was added 5% Pt—C (20 mg), hydrogenated for 16 h at 20 psi. The reaction mixture was filtered off through celite, washed with MeOH and concentration of the filtrate gave 2:1 ratio of geometrical isomers of 5-methyl-tetrahydro-pyran-2-carboxylic acid (37 mg, 91%).

Provenance & Evidence