HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N,4-dimethyl-5-pyridin-3-yl-4H-1,2,4-triazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| Reactant | N-amino-N',N''-dimethyl-guanidine | HCID 415738 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N,4-dimethyl-5-pyridin-3-yl-4H-1,2,4-triazol-3-amine | HCID 57837974 | — |
Reaction Steps
A mixture of N-amino-N′,N″-dimethyl-guanidine (500 mg, 2.17 mmol) [J. Amer. Chem. Soc.; 1951; p. 1858] and nicotinoyl chloride hydrochloride (385 mg, 2.17 mmol) in pyridine (10 mL) was refluxed o.n. Aq. sat. K2CO3 was added and the mixture extracted with CHCl3. The organic phase was dried and concentrated. The crude product 240 mg (61%) was used in the next step without further purifications.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585881B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-55d2d62ef1dd417c82885a35736ed1dc |
| Source note | uspto-grants-2009_09 |