反应详情

温度

60 °C

4-cyclopropyl-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione (11.11 g, 51 mmol) was slowly added to wet Raney nickel (90 g ) in EtOH (200 mL) in portions. The reaction mixture was heated at 60° C. for 3.5 h and then filtered through celite. The filtrate was concentrated to give the title compound (6.85 g, 72.3%). 1H-NMR: 8.76 (d, 2H), 8.71 (s, 1H), 7.95 (d, 2H), 3.75(m, 1H), 1.08 (m, 2H) and 0.94 (m, 2H).

1. filtrationfiltered through celite
2. concentrationThe filtrate was concentrated