Cesium carbonate → HCID 11596097, compound

Participants

Reaction Conditions

Reaction Steps

1.45 g (6.08 mmol) 4-[4-Methyl-5-(methylsulfonyl)-4H-1,2,4-triazol-3-yl]pyridine, 1.73 g (7.70 mmol) 1-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]ethanol and 4.03 g (12.3 mmol) cesium carbonate were dissolved under Ar-atmosphere in DMF (25 mL) and stirred at 30° C. for 3 d. After filtration and evaporation to dryness the crude was purified on 4mm silica chromatotron plate (DCM/MeOH=100/0 to 90/10). Further purification on 2 mm silica chromatotron plate (Hep/EA/MeOH=15/15/1) gave 0.36 g (15%) of the title compound. 1H NMR: 8.75 (br s, 2 H), 8.12 (s, 1 H), 8.00 (d, 1 H), 7.64 (d, 2 H), 7.56 (d, 1 H), 7.46 (t, 1 H), 6.39 (q, 1 H), 3.63 (s, 3 H), 1.94 (d, 3 H).

Provenance & Evidence