Propylamine → HCID 23143269, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-5-methyl-4-phenyl-1,3-oxazole (1.46 g, 7.56 mmol) in ethanol (15 mL) was added propylamine (5 mL), and the mixture was stirred in a sealed tube at 110° C. for 8 hr. The reaction mixture was concentrated and water was added. The mixture was extracted with ethyl acetate, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=2:1) to give the title compound (850 mg, yield 52%) as a yellow powder.

Provenance & Evidence