Hydrochloric Acid → HCID 57837926, compound

Participants

Reaction Steps

A mixture of methyl 3-{4-[(4-{[(4-isopropyl-1,3-thiazol-2-yl)(2-phenylethyl)amino]methyl}benzyl)oxy]phenyl}propanoate (350 mg), 2N aqueous sodium hydroxide solution (2 mL) and ethanol (5 mL) was stirred at room temperature for 1 hr. The reaction mixture was diluted with water, neutralized with 1N hydrochloric acid, and extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate and concentrated to give the title compound (210 mg, yield 62%) as colorless crystals.

Provenance & Evidence