HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenepropanoic acid, 4-hydroxy-, methyl ester → Methyl 3-{4-[(4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}benzyl)oxy]phenyl}propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenepropanoic acid, 4-hydroxy-, methyl ester | HCID 79706 | — |
| Reactant | (4-([(4-Phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}phenyl)methanol | HCID 23143295 | — |
| Product | Methyl 3-{4-[(4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}benzyl)oxy]phenyl}propanoate | HCID 23143288 | 57% |
Reaction Steps
The title compound was synthesized in the same manner as in Example 8 from (4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}phenyl)methanol and methyl 3-(4-hydroxyphenyl)propanoate by Mitsunobu reaction (yield 57%). Yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585880B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-0eb6a71bc6ad415ea62f9cdb7fbd562b |
| Source note | uspto-grants-2009_09 |