Water → Methyl 3-{4-[(4-{[(2-phenylethyl)(4-propyl-1,3-thiazol-2-yl)amino]methyl}benzyl)oxy]phenyl}propanoate

Beteiligte Stoffe

Reaktionsschritte

To a solution of N-(2-phenylethyl)-4-propyl-1,3-thiazole-2-amine (246 mg) in N,N-dimethylformamide (2 mL) was added sodium hydride (40 mg), and the mixture was stirred at room temperature for 1 hr. Methyl 3-(4-{[4-(chloromethyl)benzyl]-oxy}phenyl)propanoate (318 mg) was added to the reaction mixture at room temperature, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was dried using a Presep Dehydration tube (manufactured by Wako Pure Chemical Industries, Ltd.), and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:19-1:1 in volume ratio) to give the title compound (380 mg) as a yellow oil.

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