HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 732233Generated: October 26, 2026
Sulfuric Acid → 5-(2-Bromopyrid-5-yl)-1-azabicyclo[3.2.1]oct-3-ene
https://huagongshe.com/reaction/732233
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 3-Hydroxy-3-(2-bromopyridin-5-yl)-1-azabicyclo[2.2.2]octane | HCID 21103247 | — |
| Product | 5-(2-Bromopyrid-5-yl)-1-azabicyclo[3.2.1]oct-3-ene | HCID 10286057 | — |
Reaction Steps
9.4 g (0.033 mol) of 3-hydroxy-3-(2-bromopyridin-5-yl)-1-azabicyclo[2.2.2]octane and 35 ml of concentrated sulfuric acid are introduced into a 100 ml three-necked flask and the mixture is heated at 190° C. for 1 h 45.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07585974B2 |
|---|
| Source dataset | uspto-grants-2009_09 |
|---|
| ORD ID | ord-43674d7fee234aa68e069381e4a2bde7 |
|---|
| Source note | uspto-grants-2009_09 |
|---|
