4-Cyanophenol → 4-((5-Chloropentyl)oxy)benzonitrile

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Reaction Steps

In the fifth step, 4-hydroxy-benzonitrile (7) is reacted with 1-bromo-5-chloropentane, and thus, 4-(5-chloro-pentoxy)-benzonitrile (8) (yield: 90%) is obtained. As such, the reaction temperature is preferably maintained in the range from 20 to 82° C., and the reaction solvent is selected from polar solvents, including dichloromethane, acetonitrile, ethylacetate, lower alcohols such as methanol, ethanol or isopropanol, ethers such as tetrahydrofuran or 1,4-dioxane, dimethylformamide, or dimethylsulfoxide, and mixtures thereof. To ensure that the above reaction occurs under a basic condition, an inorganic base, including potassium carbonate, sodium hydroxide, potassium hydroxide, sodium amide, sodium hydride, sodium methoxide, or sodium ethoxide, and other base, may be used.

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