Sodium Hydroxide → HCID 57838365, compound

HRID 732255Notes

Reaction equation

HRID 732255 reaction equation
Cl.[CH2:2]([O:4][C:5]1[C:6]([F:18])=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH2:15][CH3:16])[C:10]([NH2:17])=[N:9][CH2:8]2)[CH3:3].[OH-].[Na+]>O>[CH2:2]([O:4][C:5]1[C:6]([F:18])=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH2:15][CH3:16])[C:10]([NH2:17])=[N:9][CH2:8]2)[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67020460HCID 67020460, compound

Product 1

HCID 57838365HCID 57838365, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 5,6-diethoxy-4-fluoro-3H-isoindol-1-ylamine hydrochloride (233 mg, 0.85 mol) and water (6 mL), a 1N aqueous solution of sodium hydroxide (2 mL) was added, and the mixture was stirred on ice for 20 minutes. Precipitated crystals were filtered and washed with water to give 85 mg of the title compound (yield: 42%) as slightly green crystals.

Workup

  1. customPrecipitated crystals
  2. filtrationwere filtered
  3. washwashed with water

Sources & evidence

ORD record
ord-65ec47941ce14279ad77d5468fd627d5
Source dataset
uspto-grants-2009_09
Patent number
US07585982B2

Reaction notes

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