Sodium Bicarbonate → 3-{(Isobutanoyloxyisobutoxy]carbonylamino}propyl(n-butyl)phosphinic Acid Sodium Salt

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Reaction Steps

Compound 39 was dissolved in a mixture of water and acetonitrile, an aqueous solution of 1 eq. NaHCO3 was added, the mixture stirred for about 10 min, and lyophilized to afford the title compound (213). 1H-NMR (400 MHz, CDCl3): δ 6.55 (d, J=4.8 Hz, 1H), 3.10 (t, J=6.4 Hz, 2H), 2.53-2.56 (m, 1H), 1.97-2.00 (m, 1H), 1.79-1.83 (m, 2H), 1.70-1.74 (m, 2H), 1.53-1.58 (m, 2H), 1.37-1.43 (m, 2H), 1.15 (t, J=6.8 Hz, 6H), 0.90 (t, J=7.2 Hz, 9H).

Provenance & Evidence