反应详情

Add thionyl chloride (5.5 mL, 75.8 mmol) to an ice-cold suspension of 4-(R)-hydroxypyrrolidine-2-(R)-carboxylic acid (4.97 g, 31.9 mmol) in methanol (60 mL). Stir 10 min, then warm to room temperature and stir 3.5 h. Concentrate, add methanol, and concentrate again. Dissolve in absolute ethanol (25 mL) and precipitate with diethyl ether (50 mL) and filter. Dry cake under vacuum to give the title compound as a white solid (4.77 g, 82%).

1. stirringstir 3.5 h
2. concentrationConcentrate
3. additionadd methanol
4. concentrationconcentrate again
5. dissolutionDissolve in absolute ethanol (25 mL)
6. customprecipitate with diethyl ether (50 mL)
7. filtrationfilter
8. customDry cake under vacuum