反应详情

Dissolve nickel chloride hexahydrate (0.021 g, 0.09 mmol) and 4-(S)-fluoro-2-(R)-(1-(R)-hydroxy-2-(S)-nitro-3-phenylpropyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.33 g, 0.897 mmol) in methanol (5 mL). Cool in an ice bath and add sodium borohydride (0.17 g, 4.485 mmol) portionwise over 1 min. Stir 10 min, then concentrate. Partition in water and ethyl acetate and filter through filter agent. Separate layers and wash organic layer with saturated aqueous sodium chloride, dry (magnesium sulfate), and concentrate to give the title compound as a white foam.

1. temperatureCool in an ice bath
2. concentrationconcentrate
3. customPartition in water
4. filtrationethyl acetate and filter
5. filtrationthrough filter agent
6. washSeparate layers and wash organic layer with saturated aqueous sodium chloride
7. dry with materialdry (magnesium sulfate)
8. concentrationconcentrate