Methanol → (2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate

Beteiligte Stoffe

Reaktionsschritte

Add thionyl chloride (5.8 mL, 79.4 mmol) to an ice-cold suspension of 4-(S)-hydroxypyrrolidine-2-(R)-carboxylic acid (4.97 g, 31.9 mmol) in methanol (70 mL). Stir 10 min, then warm to room temperature and stir 3.5 h. Concentrate, add methanol and concentrate again to give the title compound as a white solid (7.18 g, 99%).

Herkunft & Nachweise