Water → HCID 68815117, compound

Participants

Reaction Steps

Add to a solution of (2R,4R)-2-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-nitropropyl]-4-(3-methoxy-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (276 mg, 0.54 mmol) in methanol (9 mL) nickel (II) chloride followed by sodium borohydride (0.082 g, 2.17 mmol). Stir reaction for 15 min, add water (1 mL) and concentrate. Partition with ethyl acetate and water and filter through a filtering agent. Rinse cake with ethyl acetate. Separate layers, dry (magnesium sulfate) and concentrate to give the title compound as a white solid (0.244 g, 94%).

Provenance & Evidence