Lithium Hydroxide → HCID 68814269, compound

Participants

Reaction Steps

Add LiOH (0.32 mL, 3M solution in water) to a solution of (R)-2-[(4S,5S)-3-Acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-methoxycarbonylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (0.1 g, 0.19 mmol) in 0.32 mL of THF and stir overnight. Remove THF under reduced pressure. Add ethyl acetate and separate the layers. Acidify the aqueous layer with citric acid pH: 3) and extract with ethyl acetate. Dry over MgSO4 and concentrate under reduced pressure to provide the title compound (0.087 g, 90%).

Provenance & Evidence