反应详情

Add 2 N NaOH (6.0 mL, 12.0 mmol) to a solution of (S)-2-sec-butylamino-6-propanesulfonyl-isonicotinic acid methyl ester (2.47 g, 7.87 mmol) in methanol (10 mL) at 0° C. Stir the mixture at room temperature for 3 h, acidify the solution to about pH=2 and concentrate to one half of the solvent. Partition the residue between ethyl acetate and water. Extract the aqueous layer with ethyl acetate (2×50 mL). Wash the combined extracts with saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound (90%).

1. concentrationconcentrate to one half of the solvent
2. customPartition the residue between ethyl acetate and water
3. extractionExtract the aqueous layer with ethyl acetate (2×50 mL)
4. washWash the combined extracts with saturated aqueous sodium chloride
5. dry with materialdry (magnesium sulfate)
6. concentrationconcentrate