HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 5-(Methyl-propylcarbamoyl)-isophthalic acid monoisopropyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 5-(Methyl-propylcarbamoyl)-isophthalic acid 1-ethyl ester 3-isopropyl ester | HCID 68814569 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 5-(Methyl-propylcarbamoyl)-isophthalic acid monoisopropyl ester | HCID 68814443 | 64.3% |
Reaction Steps
Stir a solution of 5-(methyl-propylcarbamoyl)-isophthalic acid 1-ethyl ester 3-isopropyl ester (149 mg, 0.4 mmol) in 0.2 N NaOH in 1:10 water:isopropanol (2.2 mL) overnight. Add 1 N lithium hydroxide (0.44 mL) and stir for 1 h at room temperature. Dilute with water and extract with dichloromethane. Acidify the aqueous with 5 N HCl, extract the aqueous with dichloromethane, dry (magnesium sulfate) and concentrate to give the title compound (79 mg, 56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585885B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-fc0e11edadbf4e1dad2551a48519feb5 |
| Source note | uspto-grants-2009_09 |