反应详情

Add a solution of diethyl-5-(hydroxymethyl)-isophthalate (5 g, 19.8 mmol) in acetone (88 mL) to a solution of NaOH (792 mg, 19.8 mmol) in ethanol (12 mL). After 4 h collect precipitate. Dissolve the precipitate in water (200 mL), add 5 N HCl to about pH=1 and collect the precipitate. Extract the aqueous with dichloromethane, combine the extracts with the precipitate and concentrate to give to give the title compound (1.9 g, 43%)

1. customAfter 4 h collect precipitate
2. dissolutionDissolve the precipitate in water (200 mL)
3. additionadd 5 N HCl to about pH=1
4. customcollect the precipitate
5. extractionExtract the aqueous with dichloromethane
6. concentrationconcentrate
7. customto give