Chlorosulfonic acid → 3-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid

HRID 732509Notes

Reaction equation

HRID 732509 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=[O:6].[Cl:12][S:13](O)(=[O:15])=[O:14]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:13]([Cl:12])(=[O:15])=[O:14])[C:10]=1[F:11])[C:5]([OH:7])=[O:6]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 705093-Bromo-4-fluorobenzoic acid

Product 1

HCID 509984803-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid

Procedure

Heat 3-bromo-4-fluorobenzoic acid (6.25 g, 26.2 mmol) in chlorosulfonic acid (15 mL) at 125° C. for 120 h. Cool to room temperature and add dropwise to about 125 mL ice water. Collect the filtered solid as the title compound.

Workup

  1. customCollect the filtered solid as the title compound

Sources & evidence

ORD record
ord-773640d4aa184f1e9f26dd93fbe89f6d
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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