反应详情

Stir the crude 5-cyclopropanecarbonyl-N-methyl-N-propyl-isophthalamic acid ethyl ester (0.38 mmol) in 1 N NaOH (1 mL) and ethanol (1 mL) for 3 h at room temperature. Dilute the mixture with water (5 mL) and wash the aqueous solution with diethyl ether (2×3 mL). Acidify with 1 N HCl (1 mL) and extract with ethyl acetate (3×5 mL). Wash the combined organic layer with saturated aqueous sodium chloride, dry (sodium sulfate) and concentrate to give the title compound as a crude residue which is used in the next step without further purification.

1. washwash the aqueous solution with diethyl ether (2×3 mL)
2. extractionAcidify with 1 N HCl (1 mL) and extract with ethyl acetate (3×5 mL)
3. washWash the combined organic layer with saturated aqueous sodium chloride
4. dry with materialdry (sodium sulfate)
5. concentrationconcentrate