反应详情

温度

60 °C

Dissolve N-methyl-N-propyl-5-tributylstannanyl-isophthalamic acid methyl ester (480 mg, 0.8 mmol), benzoyl chloride (117 mg), tris(dibenzylideneacetone)dipalladium (0) (19.3 mg) and 2-(di-tert-butylphosphino)biphenyl (34.5 mg) in chloroform (8 mL) in a previously degassed sealed vessel. Flush the mixture with nitrogen and heat the sealed mixture overnight at 60° C. Cool the reaction to room temperature and filter though a filtering agent. Concentrate the filtrate and purify (silica gel chromatography, eluting with 0:100 to 30:70 ethyl acetate:hexanes) to give the title compound (66%).

1. customa previously degassed
2. customsealed vessel
3. customFlush the mixture with nitrogen
4. temperatureCool
5. customthe reaction to room temperature
6. filtrationfilter though a filtering agent
7. concentrationConcentrate the filtrate
8. custompurify
9. wash(silica gel chromatography, eluting with 0:100 to 30:70 ethyl acetate:hexanes)