Sodium Hydroxide → HCID 68814623, compound

HRID 732558Notes

Reaction equation

HRID 732558 reaction equation
C[O:2][C:3](=[O:22])[C:4]1[CH:16]=[C:15]([C:17](=[O:21])[C:18]([CH3:20])=[CH2:19])[CH:14]=[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])[CH:5]=1.[OH-].[Na+]>CO>[CH3:13][N:9]([CH2:10][CH2:11][CH3:12])[C:7](=[O:8])[C:6]1[CH:5]=[C:4]([CH:16]=[C:15]([C:17](=[O:21])[C:18]([CH3:20])=[CH2:19])[CH:14]=1)[C:3]([OH:22])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium Hydroxide2×HCID 68816243HCID 68816243, compound

Product 1

HCID 68814623HCID 68814623, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolve N-methyl-5-(2-methylacryloyl)-N-propyl-isophthalamic acid methyl ester (50 mg, 0.16 mmol) in methanol (3 mL). Add 2 N NaOH (0.12 mL) and stir overnight at room temperature. Add 2 N NaOH (0.05 mL) and stir for an additional 3 h. Acidify the mixture to about pH=6 using DOWEX® 50WX2-100 ion exchange resin and filter. Concentrate filtrate to give the title compound which is used in the next step without further purification.

Workup

  1. stirringstir for an additional 3 h
  2. filtrationfilter

Sources & evidence

ORD record
ord-657d2bbda1b143f692df13baea426a2c
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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