HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Acetyl-N-methyl-N-propyl-isophthalamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Acetyl-N-methyl-N-propyl-isophthalamic acid ethyl ester | HCID 68816950 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Acetyl-N-methyl-N-propyl-isophthalamic acid | HCID 57529285 | 101.5% |
Reaction Steps
Treat a solution of 5-acetyl-N-methyl-N-propyl-isophthalamic acid ethyl ester (196 mg, 0.67 mmol) in ethanol (7 mL) at room temperature with 2 N NaOH (0.5 mL, 1.0 mmol) for 12 h. Acidify to about pH=3 using 1 N HCl. Extract with ethyl acetate (50 mL), dry (magnesium sulfate) and concentrate to give the title compound (179 mg, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585885B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-41bc906b1a6c4ca69e9b28db121bea72 |
| Source note | uspto-grants-2009_09 |