HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Dibenzylamino-6-fluoro-N-methyl-N-propyl-isophthalamic acid ethyl ester → 5-Amino-6-fluoro-N-methyl-N-propyl-isophthalamic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Dibenzylamino-6-fluoro-N-methyl-N-propyl-isophthalamic acid ethyl ester | HCID 68814435 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Amino-6-fluoro-N-methyl-N-propyl-isophthalamic acid ethyl ester | HCID 68815144 | — |
Reaction Steps
Dissolve 5-dibenzylamino-6-fluoro-N-methyl-N-propyl-isophthalamic acid ethyl ester (275 mg, 0.595 mmol) in ethanol (6 mL). Add 10% Pd/C to the solution (50 mg). Stir the black slurry under a balloon containing hydrogen gas for 2.5 days. Filter the slurry through a pad of filtering agent and wash with ethanol. Concentrate the filtrate to give the title compound as a crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585885B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-585ddf66504941569a0583bd25da71e8 |
| Source note | uspto-grants-2009_09 |