HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-{(1S,2R)-1-(3,5-Difluoro-benzyl)-2-hydroxy-2-[(2R,4R)-4-(3-trifluoromethoxy-benzyloxy)-pyrrolidin-2-yl]-ethyl}-acetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (2R,4R)-2-[(4S,5S)-3-Acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-(3-trifluoromethoxy-benzyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 68817268 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-{(1S,2R)-1-(3,5-Difluoro-benzyl)-2-hydroxy-2-[(2R,4R)-4-(3-trifluoromethoxy-benzyloxy)-pyrrolidin-2-yl]-ethyl}-acetamide hydrochloride | HCID 86615018 | 100% |
Reaction Steps
Add 4M hydrogen chloride in dioxane (5 mL) to (2R,4R)-2-[(4S,5S)-3-acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-(3-trifluoromethoxy-benzyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.138 g, 0.22 mmol). Stir 18 h and concentrate to give the title compound as a foam (0.11 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585885B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-3f127e93b1ee4292a2106ffc20276dc8 |
| Source note | uspto-grants-2009_09 |