Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (4S)-4-benzyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Lithium Chloride | HCID 433294 | — |
| 반응물 | (S)-4-Benzyl-2-oxazolidinone | HCID 736225 | — |
| 반응물 | Cinnamoyl Chloride | HCID 5354261 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (4S)-4-benzyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one | HCID 10470464 | — |
반응 단계
In accordance with the method of “Helvetica Chimica Acta”, 2002, vol. 85, no. 11, p. 3616-3623, triethylamine was added under ice-cooling to a mixture of trans-cinnamic acid chloride, (S)-4-benzyl-2-oxazolidinone, lithium chloride and dichloromethane, and then stirred at room temperature for 3Hours. Thereafter, (4S)-4-benzyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one was obtained by purifying it in the standard method. FP: 308.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07585886B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-e9ff606c070a456d9ba7bf190b49e00d |
| 출처 메모 | uspto-grants-2009_09 |