1,4-Dioxane hydrochloride → [4-(Ethoxycarbonyl)piperidin-1-yl]acetic acid

HRID 732632Notes

Reaction equation

HRID 732632 reaction equation
Cl.[O:2]1CCOCC1.C([C:12](=[O:25])[CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:16][CH2:15]1)(C)(C)C>O1CCOCC1>[CH2:23]([O:22][C:20]([CH:17]1[CH2:16][CH2:15][N:14]([CH2:13][C:12]([OH:25])=[O:2])[CH2:19][CH2:18]1)=[O:21])[CH3:24]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68912756HCID 68912756, compound

Product 1

HCID 52903749[4-(Ethoxycarbonyl)piperidin-1-yl]acetic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

At room temperature, 3.0 ml of 4 M hydrogen chloride/1,4-dioxane was added to 8 ml of 1,4-dioxane solution containing 543 mg of ethyl 1-(2-tert-butyl-2-oxoethyl)piperidine-4-carboxylate, and stirred at 60° C. for 8Hours. The thus formed solid was collected by filtration to obtain 300 mg of [4-(ethoxycarbonyl)piperidin-1-yl]acetic acid as a white solid. EP: 216.

Workup

  1. filtrationThe thus formed solid was collected by filtration

Sources & evidence

ORD record
ord-a375a20b99534bbfbf58b7fa2a2e34a3
Source dataset
uspto-grants-2009_09
Patent number
US07585886B2

Reaction notes

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