HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 732635Generated: October 31, 2026
3-Hydroxybenzaldehyde → 4-(3-Formylphenoxy)benzonitrile
https://huagongshe.com/reaction/732635
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Hydroxybenzaldehyde | HCID 101 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(3-Formylphenoxy)benzonitrile | HCID 13238540 | — |
Reaction Steps
A 1.2 g portion of 4-fluorobenzonitrile and 1.0 g of potassium carbonate were added to 25 ml DMF solution of 1.2 g of 3-hydroxybenzaldehyde and stirred overnight with heating at 100° C. The reaction solution was poured into ice water, and then work-up and purification were carried out in the standard method to obtain 1.6 g of 4-(3-formylphenoxy)benzonitrile as an oily substance. EI: 223.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07585886B2 |
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| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-e0a7980e592b4d2f89b3defcd4a442d3 |
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| Source note | uspto-grants-2009_09 |
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