Ammonium Chloride → HCID 68912212, compound

HRID 732644Notes

Reaction equation

HRID 732644 reaction equation
[N:1]1([C:7]2[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:8]=2[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl-].[NH4+]>C(O)C.O>[NH2:18][C:16]1[CH:15]=[CH:14][C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([N:1]2[CH2:2][CH2:3][O:4][CH2:5][CH2:6]2)[CH:17]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 68911598HCID 68911598, compound

Product 1

HCID 68912212HCID 68912212, compoundYield 47.6%

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1.16 g of ethyl 2-morpholin-4-yl-4-nitrobenzoate, 1.1 g of ammonium chloride, 1.0 g of reduced iron and 14 ml of ethanol-water (5:2) mixed solvent was stirred at 80° C. for 4Hours. The reaction solution was filtered while hot, and the white crystals precipitated after spontaneous cooling were collected by filtration to obtain 493 mg of ethyl 4-amino-2-morpholin-4-ylbenzoate. EP: 251.

Workup

  1. additionmixed solvent
  2. filtrationThe reaction solution was filtered while hot, and the white crystals
  3. customprecipitated
  4. temperatureafter spontaneous cooling
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-88e730e386c340e8bf2eedf59d1b3e15
Source dataset
uspto-grants-2009_09
Patent number
US07585886B2

Reaction notes

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