HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[(1R)-1-(3-Methoxyphenyl)ethyl]-2-nitrobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| Reactant | (R)-1-(3-Methoxyphenyl)ethylamine | HCID 7020759 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[(1R)-1-(3-Methoxyphenyl)ethyl]-2-nitrobenzenesulfonamide | HCID 68910516 | 98.9% |
Reaction Steps
A 2.0 ml portion of triethylamine and 1.9 g of orthonitrobenzenesulfonyl chloride were added to a mixed solution of 1.0 g of (1R)-1-(3-methoxyphenyl)ethylamine and 10 ml of dichloromethane under ice-cooling and stirred for 5Hours. Thereafter, work-up and purification were carried out in the standard method to obtain 2.2 g of N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-nitrobenzene sulfonamide as yellow crystals. EN: 335.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585886B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-c84ad1aefed14e22bd83a4af41b2c9cb |
| Source note | uspto-grants-2009_09 |