Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Acetyl-2-chloro-1-methylindole | HCID 820344 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 68916201 | HCID 68916201 | 75% |
Reaction Steps
A 203 mg portion of sodium hydride (60% oil dispersion) and 734 mg of 1-(2-chloro-1-methyl-1H-indol-3-yl)ethanone synthesized from oxyindole in accordance with the method of “European Journal of Medicinal Chemistry”, 1991, vol. 26, p. 179-188, were added in that order at room temperature to a mixed solution of 498 mg of phenol and 10 ml of dimethylacetamide and stirred at 90° C. for 2Hours. Thereafter, its work-up and purification were carried out in the standard method to obtain 703 mg of 1-(1-methyl-2-phenoxy-1H-indol-3-yl)ethanone as a colorless solid. EP: 266.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07585886B2 |
|---|
| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-8b3a33b61d594caa885aabca59347d2f |
|---|
| Source note | uspto-grants-2009_09 |
|---|
