Methyl 1-benzyl-5-oxopyrrolidine-3-carboxylate → (1-Benzylpyrrolidin-3-yl)methanol

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Reaction Conditions

Reaction Steps

In accordance with the technique of “Bioorganic and Medicinal Chemistry Letters”, 1991, vol. 1, no. 12, p. 757-760, methyl 1-benzyl-5-oxopyrrolidine-3-carboxylate (mfd. by Aldrich, USA) was added to a THF solution of lithium aluminum hydride in an ice bath, and then stirred at 60° C. for 1.5Hours. Thereafter, its work-up and purification were carried out in the standard method to obtain (1-benzylpyrrolidin-3-yl)methanol. FP: 192.

Provenance & Evidence