HuagongsheHuagongshe Chemistry Print Report · For research reference only
Itaconic acid → 5-Oxo-1-phenylpyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Itaconic acid | HCID 811 | — |
| Reactant | Aniline | HCID 6115 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 5-Oxo-1-phenylpyrrolidine-3-carboxylic acid | HCID 2737107 | — |
Reaction Steps
In accordance with the method of “Journal of the American Chemical Society”, vol. 72, 1950, p. 1415, aniline was added to an itaconic acid aqueous solution and heated under reflux for 12Hours. After completion of the reaction, this was ice-cooled and mixed with 70 ml of 1 M hydrochloric acid, and the thus precipitated crystals were collected by filtration to obtain 5-oxo-1-phenylpyrrolidine-3-carboxylic acid. EP: 206.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585886B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-07d2cc70a1f94326b7e699da61517154 |
| Source note | uspto-grants-2009_09 |