HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 4-(Hydroxymethyl)-1-phenylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 5-Oxo-1-phenylpyrrolidine-3-carboxylic acid | HCID 2737107 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(Hydroxymethyl)-1-phenylpyrrolidin-2-one | HCID 10012763 | — |
Reaction Steps
1,1′-Carbonylbisimidazole was added to a THF solution of 5-oxo-1-phenylpyrrolidine-3-carboxylic acid and stirred at room temperature for 1.5Hours. Successively sodium borohydride and 2.0 ml of water were added thereto and stirred at room temperature for 1Hour. Thereafter, its work-up and purification were carried out in the standard method to obtain 4-(hydroxymethyl)-1-phenylpyrrolidin-2-one. EP: 192.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585886B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-485876b4307e437ebc8428f659494de1 |
| Source note | uspto-grants-2009_09 |