1,4-Dioxane hydrochloride → HCID 68914366, compound

HRID 732673Notes

Reaction equation

HRID 732673 reaction equation
[ClH:1].O1CCO[CH2:4][CH2:3]1.Cl.[C:9]1([C@H:19]([NH:21][CH2:22][C@@H:23]2[C@@H:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:26][N:25]([C:34](=[O:42])[CH2:35][CH2:36][CH2:37][CH2:38][C:39]([OH:41])=[O:40])[CH2:24]2)[CH3:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1>C(O)C>[ClH:1].[C:9]1([C@H:19]([NH:21][CH2:22][C@@H:23]2[C@@H:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:26][N:25]([C:34](=[O:42])[CH2:35][CH2:36][CH2:37][CH2:38][C:39]([O:41][CH2:3][CH3:4])=[O:40])[CH2:24]2)[CH3:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68914504HCID 68914504, compound

Product 1

HCID 68914366HCID 68914366, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 2.0 ml portion of 4 M hydrogen chloride/1,4-dioxane was added to a 5.0 ml ethanol solution of 200 mg of 6-[(3S,4S)-3-({[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-4-phenylpyrrolidin-1-yl]-6-oxohexanoic acid hydrochloride and stirred at room temperature for 1Hour. By evaporating the solvent and crystallizing the residue from ethyl acetate-hexane, 154 mg of ethyl 6-[(3S,4S)-3-({[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-4-phenylpyrrolidin-1-yl]-6-oxohexanoate hydrochloride was obtained as a colorless solid.

Workup

  1. customBy evaporating the solvent
  2. customcrystallizing the residue from ethyl acetate-hexane

Sources & evidence

ORD record
ord-59a6ae7bc1234465b6e947bb7b3a2e98
Source dataset
uspto-grants-2009_09
Patent number
US07585886B2

Reaction notes

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