反应详情

A 162 ml portion of 0.1 M potassium hydroxide aqueous solution was added to a 50 ml methanol solution of 3.01 g of dimethylpyridine-3,5-dicarboxylate and stirred at room temperature for 3Hours. The reaction solution was washed with diethyl ether, and the aqueous layer was concentrated under a reduced pressure. The residue was mixed with ethanol and stirred at 50° C. for 15Hours. The insoluble matter was removed by filtration, and then the filtrate was concentrated under a reduced pressure to obtain 2.51 g of potassium 5-(methoxycarbonyl)nicotinate as white crystals.

1. washThe reaction solution was washed with diethyl ether
2. concentrationthe aqueous layer was concentrated under a reduced pressure
3. additionThe residue was mixed with ethanol
4. stirringstirred at 50° C. for 15Hours
5. customThe insoluble matter was removed by filtration
6. concentrationthe filtrate was concentrated under a reduced pressure