Diethyl Ether → HCID 86628562, compound

Participants

Reaction Steps

A 470 mg portion of (1R)-1-(1-naphthyl)-N-{[(3R,4R)-4-phenyl-1-(trifluoroacetyl)pyrrolidin-3-yl]methyl}ethanamine was dissolved in 8 ml of ethyl acetate and treated with 4 M hydrogen chloride/ethyl acetate solution. Diethyl ether was added to the reaction solution, and the thus precipitated crystals were recrystallized from ethyl acetate and diethyl ether to obtain 258 mg of (1R)-1-(1-naphthyl)-N-{[(3R,4R)-4-phenyl-1-(trifluoroacetyl)pyrrolidin-3-yl]methyl}ethanamine hydrochloride as colorless crystals.

Provenance & Evidence