Trifluoroacetic acid → HCID 59751438, compound

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Reaction Steps

In a round bottom flask place the product of Example 68 (80 mg, 0.13 mmol) and trifluoroacetic acid (5 mL). Heat this solution at reflux for 15-20 minutes then cool to ambient temperature. Quench the reaction mixture by pouring it over saturated aqueous sodium bicarbonate then extract into ethyl acetate. Wash the combined extracts with saturated aqueous sodium bicarbonate, water and brine; then dry (sodium sulfate) and evaporate in vacuo. Purify the resulting material on a Chromatotron (silica gel; 4%-8% MeOH gradient in CH2Cl2) to obtain 63 mg of the title compound (89%). MS (IS+) m/e 547 (M+1).

Provenance & Evidence