Pyridinium chloride → HCID 68517771, compound

Participants

Reaction Conditions

Reaction Steps

Add pyridine hydrochloride (4.0 g) to the compound of Example 74 (100 mg, 0.18 mmol). Purge the vessel with nitrogen, cap it, and heat to 200° C. for 4 hours. Cool to room temperature and dilute with saturated aqueous NaHCO3. Extract with 25% isopropanol (i-PrOH) in CHCl3, dry over Na2SO4 and concentrate in vacuo. Purify using an SCX column (eluting with 2M NH3/MeOH) followed by flash chromatography (0-10% MeOH/CHCl3). Dissolve the product in 1:1 CH3CN/1M aqueous HCl and lyophilize to yield 70.3 mg of the title compound (68%). LCMS: m/z=530 (M+H)+.

Provenance & Evidence