Trifluoroacetic acid → HCID 11649435, compound

Participants

Reaction Steps

Dissolve the compound of Example 76 (185.2 mg, 0.33 mmol), Et3SiH (0.3 mL, 1.88 mmol) and TFA (0.3 mL, 3.8 mmol) in CH2Cl2 (30 mL). Stir at room temperature for 1 hour. Quench with saturated aqueous NaHCO3 and extract with 25% i-PrOH in CH2Cl2. Dry over Na2SO4, filter and concentrate. Purify the crude material by flash chromatography (0-5% MeOH/CH2Cl2 to afford 1.18 g of the title compound (63%). LCMS: m/z=530 (M+H)+

Provenance & Evidence