Ammonium formate → Carbamic acid, [6-[(4-aminobenzoyl)amino]hexyl]-, 1,1-dimethylethyl ester

Participants

Reaction Steps

The above amide (265 mg, 0.750 mmol) was dissolved in EtOH (25 mL). The reaction mixture was charged with ammonium formate (500 mg) and 10% palladium on carbon (100 mg) and stirred for 4 days at ambient temperature. The reaction was filtered through diatomaceous earth and concentrated to recover 265 mg of [6-(4-amino-benzoylamino)-hexyl]-carbamic acid tert-butyl ester as a white crystalline solid (quantitative yield).

Provenance & Evidence