反应详情

1.6 ml of TMEDA (15 mmol.) are added to a suspension of 1.86 g (10 mmol.) of N-mesitylimidazole in 30 ml of hexane. 6.25 ml of 1.6 molar n-butyllithium solution (10 mmol.) are added at room temperature. The mixture is then heated for 2.5 hours at reflux temperature (solution 1). In another flask, 2.2 ml (10 mmol.) of dicyclohexylchlorophosphane are mixed with 20 ml of hexane and heated to 60° C. (solution 2). The boiling solution 1 is then slowly transferred into solution 2, which is at 60° C., by means of a cannula. The mixture is then boiled for a further 1 hour at reflux, the solution is cooled, and 20 ml of degassed water are added thereto. The organic phase is filtered off over magnesium sulfate. The solution is concentrated in vacua; 30 ml of pentane are added thereto, and the mixture is boiled for 1 hour at reflux. The product precipitates in crystalline form at −30° C. and is filtered off while cold. Yield: 2.48 g (65%)

1. temperatureThe mixture is then heated for 2.5 hours
2. customis at 60° C., by means of a cannula
3. temperatureat reflux
4. temperaturethe solution is cooled
5. filtrationThe organic phase is filtered off over magnesium sulfate
6. concentrationThe solution is concentrated in vacua
7. addition30 ml of pentane are added
8. waitthe mixture is boiled for 1 hour
9. temperatureat reflux
10. customThe product precipitates in crystalline form at −30° C.
11. filtrationis filtered off while cold