HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → 3,4-Difluorophenyl 4-(prop-2-ynyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3,4-Difluorophenol | HCID 75927 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Product | 3,4-Difluorophenyl 4-(prop-2-ynyl)piperidine-1-carboxylate | HCID 57838890 | — |
Reaction Steps
3,4-Difluoro-phenol (3.85 g, 29.6 mmol) was added as a solution in THF and dimethylaniline to a mixture of triphosgene (2.849 g, 9.6 mmol) in THF according to general procedure 3. Yield=4.6 g, 56%. m/z MH+=280.15. HPLC rt=11.88 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07589076B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-3b377008d12b40488331652419871973 |
| Source note | uspto-grants-2009_09 |